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desvenlafaxine will improve the level or result of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Observe. Desvenlafaxine inhibits CYP2D6; with greater desvenlafaxine doses (ie, 400 mg) reduce the CYP2D6 substrate dose by approximately 50%; no dosage adjustment desired with desvenlafaxine doses 7 consecutive days immediately p